Aerodynamic particle size analysis of a metered dose inhalation containing 100μg salbutamol sulphate in a single dose

The product beingness tested is a salamol chlorofluorocarbon-free Easi-Breathe respirator each actuation of the inhalator delivers Salbutamol Sulphate Ph Eur equivalent to Salbutamol atomic number 6 micrograms into the mouthpiece of the adapter. Salbutamol is a selective ?2-adrenoceptor agonist. At therapeutic panes it acts on the ?2-adrenoceptors of bronchial glint muscle providing short acting (4-6 hour) bronchodilatation with a fast trespass (within 5 minutes) in reversible airways obstruction. Salamol is indicated in the management of bronchial asthma, for the relief of wheezing and shortness of pinch apply on an as required basis. The inhaler whitethorn be used as necessary to relieve attacks of neat dyspnoea and may be used prophylactically before feat or to counter exercise-induced asthma. The inhaler may also be used in the treatment of the reversible component of airways obstruction. The metered dose inhaler (MDI) being is used in this experiment is the sala mol inhaler as antecedently mentioned. It is a relatively new inhaler on the British market. The contents of the MDI are Norflurane (HFA 134a) Ethanol anhydrous and Salbutamol Sulphate. The inhaler asks a new propellant and does not contain chlorofluorocarbons (CFCs). In the past the chief(prenominal) propellants used in inhalers were all CFC based which had a detrimental effect on the Ozone layer.

out-of-pocket to the International ordinance of the Montreal Protocol, an international agreement on targets for the emptying of CFCs and HCFCs signed by 58 countries in 1990, the pharmaceutic labor are presently e xempted from this ban on CFCs, but this res! istance is reviewed annually. This has forced the pharmaceutical industry to seek more ozone hearty propellants. The norflurane (HFA 134a) acts as the propellant, in the easi-breathe, which is a hydroflurocarbon (HFA) and is Ozone friendly. The drug substance is outspread in the propellant, upon dot the propellant and the drug are dispersed... If you compulsion to get a full essay, order it on our website: OrderCustomPaper.com

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